Description
Available Combinations & Strengths:
- ALENZA-FX
Montelukast 10 mg + Fexofenadine 120 mg Film-Coated Tablet
ALENZA-FX TABLETS
Introduction:
- ALENZA-FX is a film-coated tablet combining Montelukast 10 mg and Fexofenadine 120 mg, used for allergy relief. It comes in a 1×10 Alu Alu strip packaging, suitable for pharmaceutical sales presentations. This combination targets allergic rhinitis symptoms like sneezing, runny nose, and nasal congestion.
- ALENZA-FX provides effective relief from seasonal and perennial allergic rhinitis by blocking leukotrienes and histamine actions. Montelukast reduces airway inflammation, while Fexofenadine alleviates sneezing and watery eyes. The product suits adults managing allergy symptomsDosage & Administration
Administer one tablet daily, preferably in the evening, for adults and children over 12 years, with or without food. Consistent timing maintains efficacy for allergy control. Follow physician guidance, as dosage may vary by patient condition.
Composition:
Each film-coated tablet contains:
- Fexofenadine – 20 mg
- Montelukast Sodium – 10 mg
Indications:
- Symptomatic relief of nasal and non-nasal symptoms of seasonal and perennial allergic rhinitis (≥12 years)
Mechanism of Action:
- Fexofenadine: Blocks peripheral H1 histamine receptors, preventing allergic symptoms like sneezing and itching without sedation.
- Montelukast: Blocks CysLT1 receptors, preventing bronchoconstriction and inflammation, thus improving airflow and reducing mucus production.
Pharmacokinetics of Fexofenadine:
Fexofenadine exhibits rapid oral absorption with peak plasma levels in 1-3 hours and ~33% bioavailability. It undergoes minimal hepatic metabolism (~5%), with 60-70% plasma protein binding and a volume of distribution of 5.4-5.8 L/kg.
Key PK Parameters
• Elimination: Primarily unchanged via feces (80%) and urine (11-12%), half-life ~14 hours.
• Transporters: Substrate for P-gp and OATPs, affecting disposition; food (high-fat) reduces absorption by 20-60%.
Dosage & Administration:
Administer one tablet daily, preferably in the evening, for adults and children over 12 years, with or without food. Consistent timing maintains efficacy for allergy control. Follow physician guidance, as dosage may vary by patient condition
Presentation:
- 1×10 strip pack
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