Description
GLOMUNE IV
L-Alanyl-L-Glutamine Infusion 20%
DESCRIPTION
GLOMUNE IV is a clear, colorless to almost colorless sterile solution of L-Alanyl-L-Glutamine, a dipeptide stable form of glutamine used in parenteral nutrition (TPN).
INDICATIONS
GLOMUNE IV is recommended as a glutamine supplement in Total Parenteral Nutrition (TPN) for critically ill patients. It supports faster recovery and reduced complications in:
- ICU patients
- Severe burn victims
- Gastrointestinal surgery patients
- Bowel obstruction cases
- Severe pancreatitis
- Cancer patients undergoing chemotherapy or with severe vomiting
- Patients with high output fistulas
MECHANISM OF ACTION
L-Alanyl-L-Glutamine provides metabolic and protective support through:
- Immunomodulatory and antioxidant effects
- Anabolic/anticatabolic actions that preserve skeletal muscle glutamine stores
- Fueling enterocytes and colonocytes, maintaining intestinal mucosal integrity
- Supporting glutathione synthesis to combat oxidative stress
CLINICAL HIGHLIGHT
A clinical study evaluated 0.5 mg/kg/day of L-Alanyl-L-Glutamine infusion for 10 days postoperatively in patients with suspected invasive fungal rhinosinusitis.
Results showed:
| Outcome Parameter | Treatment Group (n=7) | Control Group (n=7) | P-value |
| ICU Stay Length (mean ± SD) | 14 ± 3 days | 20 ± 3 days | 0.003* |
| Complication Rate (%) | 29% | 86% | 0.03* |
Significant clinical improvement in recovery and reduced ICU duration and complications.
DOSAGE
1.5 – 2.0 ml/kg body weight/day
Equivalent to 0.3 – 0.4 g/kg of L-Alanyl-L-Glutamine.
ADMINISTRATION
- With TPN:
Mix in 1:5 ratio (e.g. 100 ml GLOMUNE + at least 500 ml amino acid solution) - Alone or with NS:
Mix in 1:1 ratio (e.g. 100 ml GLOMUNE + 100 ml NS)
INFUSION RATE
Administer at 0.5 ml/min
(50 ml bottle to be infused over 2 hours)
PRESENTATION
50 ml glass bottle
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