Description
Meropenem Injection I.P. 1 g
MEROMIX™ (Meropenem for Injection) is a sterile, pyrogen-free, synthetic broad-spectrum carbapenem antibiotic for intravenous administration. It is effective against a wide range of gram-positive and gram-negative pathogens, including anaerobes.
Indications:
Meropenem I.V. is indicated as single-agent therapy for the treatment of:
- Complicated Appendicitis and Peritonitis
in adults and pediatric patients (≥3 months) caused by:- Viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus
- Complicated Skin and Skin Structure Infections
in adults and pediatric patients (≥3 months) caused by:- Staphylococcus aureus (β-lactamase and non-β-lactamase producing, methicillin-susceptible strains only)
- Bacterial Meningitis
in pediatric patients (≥3 months) caused by:- Streptococcus pneumoniae, Haemophilus influenzae (both β-lactamase positive and negative strains)
Mechanism of Action:
Meropenem acts by inhibiting bacterial cell wall synthesis, leading to bactericidal activity against a broad spectrum of gram-positive and gram-negative bacteria, including anaerobes.
Dosage and Administration:
Adults:
| Indication | Dose | Frequency | Duration |
| Intra-abdominal infections | 1 g | Every 8 hrs | 7–14 days |
| Nosocomial pneumonia | 1 g | Every 8 hrs | 4–7 days |
| Skin/Soft tissue infections | 500 mg–1 g | Every 8 hrs | 7–10 days |
| Cystic fibrosis | 1 g | Every 8 hrs | 7–10 days |
| Meningitis | 1 g | Every 8 hrs | 7–21 days |
| MIC > 4 mg/mL | 1 g | Every 8 hrs | 7–21 days |
Renal Dose Adjustments (Adults):
| Creatinine Clearance (CrCl) | Dose | Frequency |
| 26–50 mL/min | 1 g | Every 12 hrs |
| 10–25 mL/min | 500 mg | Every 12 hrs |
| <9 mL/min | 500 mg | Every 24 hrs |
Pediatric Patients (≥3 months):
| Indication | Dose | Frequency |
| Intra-abdominal infections | 20 mg/kg | Every 8 hrs |
| Meningitis | 40 mg/kg | Every 8 hrs |
| Skin and soft tissue infection | 10 mg/kg | Every 8 hrs |
Presentation:
- MEROMIX™ 1 g vial with Sterile Water for Injection
Clinical Notes:
- Studies support prolonged infusion (3 hours) of 1 g every 8 hours for improved clinical efficacy.
- Safe use of high cumulative daily doses has been demonstrated in clinical settings such as cystic fibrosis.
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