Background:

CHOMEBRIN is a hard gelatin capsule that combines:

  • Chlordiazepoxide 5 mg – a psychotropic agent (anxiolytic)
  • Mebeverine Hydrochloride 135 mg (Sustained Release) – a synthetic anticholinergic with direct antispasmodic action

Description

Chlordiazepoxide 5 mg & Sustained Release Mebeverine Hydrochloride 135 mg Capsules

INDICATIONS:

CHOMEBRIN is indicated for the management of:

  • Irritable Bowel Syndrome (IBS)
  • Abdominal pain, spasms, flatulence, and discomfort related to IBS
  • Excessive tension and anxiety associated with gastrointestinal conditions

MECHANISM OF ACTION:

Chlordiazepoxide:

  • Binds to benzodiazepine (BZD) receptors on the GABA-A receptor complex in the central nervous system (CNS)
  • Enhances the action of GABA, increasing chloride ion influx and producing sedative, anxiolytic, and muscle relaxant effects
  • Helps normalize excessive excitatory activity, reducing stress-related IBS symptoms

Mebeverine (Sustained Release):

  • A direct-acting smooth muscle relaxant
  • Reduces gastrointestinal motility and spasms without affecting normal gut movement
  • Also helps in decreasing gastric acid secretion, providing relief from IBS symptoms

DOSAGE:

As directed by the physician.

PRESENTATION:

Available in hard gelatin capsule form.

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